|
Education:
- Ph. D. 1987 Cornell University, Ithaca, NY, Analytical Chemistry
- M. S. 1985, Cornell University, Ithaca, NY, Analytical Chemistry
- B. S. 1982, Clarkson University, Potsdam, NY, Chemistry
--------------------------------------------------------------------------------
Positions Held:
- 2002-present Member, UCLA Jonsson Comprehensive Cancer Center
- 2002-present Member, UCLA Molecular Biology Institute
- 2001-present Member, UCLA/DOE Laboratory for Genomics and Proteomics
- 2001-present Director, UCLA Mass Spectrometry and Proteomics Technology Center
- 2001-present Director, UCLA Mass Spectrometry and Proteomics Technology Center
- 2001-present Professor, University of California, Los Angeles, CA (Dept. Biological Chemistry and Dept. Chemistry & Biochemistry)
- 1992-2001 Associate Research Fellow, Biological Mass Spectrometry Group Leader, Proteomics Team Co-Leader, Parke-Davis Pharmaceutical (currently Pfizer Global Research and Development), Ann Arbor, MI
- 1990-1992 Senior Research Scientist, Battelle-Pacific Northwest National Laboratory, Richland, WA
- 1988-1990 Postdoctoral Fellow, Battelle-Pacific Northwest National Laboratory (Dr. R. D. Smith)
- 1987-1988 Postdoctoral Fellow, Cornell University (Prof. Fred W. McLafferty)
--------------------------------------------------------------------------------
Awards and Honors:
- 1993 Allan Maccoll Organic Mass Spectrometry Journal Award (best paper)
- 1983 Chemistry Teaching Assistant Award, Cornell University
- 1982 Stephen Brunauer Senior Thesis Award, Clarkson University
- 1982 Merck Chemistry Award, Clarkson University
Selected Professional Activities:
- 2000-2004 Member, NIH Bioanalytical Engineering & Chemistry Special Emphasis Panel (BECM SEP)
- 2000-2002 Member, ASMS Board of Directors
- 2000 Ad Hoc Reviewer, NIH-NCRR Shared Instrumentation Grant (S10)
- 1999 Ad Hoc Reviewer, NIH-NIAID R21 - “Immunological Phenotyping of Mouse Mutants”
- 1999 Ad Hoc Reviewer, NIH-NCRR Shared Instrumentation Grant (S10)
- 1998-2000 American Society for Mass Spectrometry (ASMS) Publications Committee
- 1997-2000 Editorial Advisory Board, Bioconjugate Chemistry
- 1997-1999 A-Page Advisory Panel, Analytical Chemistry
- 1996-1998 Editorial Board, Journal of the American Society for Mass Spectrometry (JASMS)
--------------------------------------------------------------------------------
Selected Research Publications (out of over 100):
- Smith RD, Loo JA, Edmonds CG, Barinaga CJ, and Udseth HR. "New Developments in Biochemical Mass Spectrometry: Electrospray Ionization." Anal Chem 1990;62:882.
- Thevis M, Ogorzalek Loo RR, and Loo JA. “In-Gel Derivatization of Proteins for Cysteine-Specific Cleavages and their Analysis by Mass Spectrometry.” J Proteome Res, in press.
- Ogorzalek Loo RR, Loo JA, Du P, and Holler T. “In Vivo Labeling: A Glimpse of the Dynamic Proteome and Additional Constraints for Protein Identification.” J Am Soc Mass Spectrom 2002; 13: 804-812.
- Loo JA, Blackledge JA, Du P, Kilby GW, Lepley RA, Macri J, Ogorzalek Loo RR, Rapundalo ST, and Stevenson TI. “Integrated Proteomics Technologies” in “Integrated Drug Discovery Technologies”, Mei H-Y and Czarnik A (Eds.), Marcel Dekker, pp 79-115, 2002.
- Ogorzalek Loo RR, Cavalcoli JD,VanBogelen RA, Mitchell C, Loo JA, Moldover B, and Andrews PC. “Virtual 2-D Gel Electrophoresis: Visualization and Analysis of the E. coli Proteome by Mass Spectrometry.” Anal Chem 2001; 73: 4063.
- Yoshida M, Loo JA, and Lepley RA. “Proteomics as a tool in the pharmaceutical drug design process.” Curr Pharm Des 2001; 7: 291.
- Loo JA. “Probing Protein-Metal Ion Interactions by Electrospray Ionization Mass Spectrometry: Enolase and Nucleocapsid Protein.” Int J Mass Spectrom 2001; 204: 113.
- Loo, JA. “Electrospray Ionization Mass Spectrometry: A Technology for Studying Noncovalent Macromolecular Complexes.” Int J Mass Spectrom 2000; 200:175.
- Loo JA, Brown J, Critchley G, Mitchell C, Andrews PC, and Ogorzalek Loo RR. “High Sensitivity Methods for Obtaining Intact Molecular Weights from Gel-Separated Proteins.” Electrophoresis 1999; 20: 743.
- Mei H-Y, Cui M, Heldsinger A, Lemrow SM, Loo JA.; Sannes-Lowery KA, Sharmeen L, Czarnik AW. “Inhibitors of Protein-RNA Complexation That Target the RNA: Specific Recognition of HIV Type 1 TAR RNA by Small Organic Molecules.” Biochemistry 1998; 37: 14204.
- Fry DW, Bridges AJ, Denny WA, Doherty A, Greis KD, Hicks JL, Hook KE, Keller PR, Leopold WR, Loo JA, McNamara DJ, Nelson JM, Sherwood V, Smaill JB, Trumpp-Kallmeyer S, and Dobrusin EM. “Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor.” Proc Natl Acad Sci USA 1998; 95: 12022.
- Loo JA, Holler TP, Foltin SK, McConnell P, Banotai CA, Horne NM, Mueller WT, Stevenson TI, and Mack DP. “Application of Electrospray Ionization Mass Spectrometry for Studying HIV Protein Complexes.” Proteins: Func, Struct, and Genetics. 1998; Suppl. 2: 28.
- Loo JA, He JX, and Cody WL. “Higher Order Structure in the Gas Phase Reflects Solution Structure.” J Am Chem Soc 1998; 120: 4542.
- Loo JA. "Studying Noncovalent Protein Complexes by ESI-MS." Mass Spectrom Rev 1997;16:1.
- Loo JA, Hu P, McConnell P, Mueller WT, Sawyer TK, and Thanabal V. "A Study of Src SH2 Domain Protein-Phosphopeptide Binding Interactions by ESI-MS." J Am Soc Mass Spectrom 1997; 8: 234.
- Loo JA, Holler TP, Sanchez J, Gogliotti R, Maloney L, and Reily MD. "Biophysical Characterization of Zinc Ejection from HIV Nucleocapsid Protein by Anti-HIV 2,2'-Dithiobis[benzamides] and Benzisothiazolones." J Med Chem 1996; 39: 4313.
- Ogorzalek Loo RR, Stevenson TI, Mitchell C, Loo JA, and Andrews PC. "Mass Spectrometry of Proteins Directly from Polyacrylamide Gels." Anal Chem 1996; 68: 1910.
- Loo JA, Ogorzalek Loo RR, and Andrews PC. “Primary to Quaternary Protein Structure Determination with Electrospray Ionization and Magnetic Sector Mass Spectrometry.” Org Mass Spectrom 1993; 28:1640.
- Ogorzalek Loo RR, Goodlett DR, Smith RD, and Loo JA. "Observation of Noncovalent Ribonuclease S-Protein/S-Peptide Complex by Electrospray Ionization MS." J Am Chem Soc 1993;115:4391.
- Loo JA, Quinn JP, Ryu SI, Henry KD, Senko MW, and McLafferty FW. "High Resolution Tandem Mass Spectrometry of Large Biomolecules." Proc Natl Acad Sci USA 1992;89:286.
- Loo JA, Edmonds CG, and Smith RD. "Tandem MS of Very Large Molecules: Serum Albumin Sequence Information from Multiply Charged Ions Formed by ESI." Anal Chem 1991;63:2488.
- Loo JA, Edmonds CG, and Smith RD. "Primary Sequence Information from Intact Proteins by Electrospray Ionization Tandem Mass Spectrometry." Science 1990;248:201.
|
